Although no difference between CYP11B2 T-344C gene polymorphism and increased AF risk was found under this genetic model, the heterogeneity was more distinct in the China subgroup (I2 = 79.5%, Pheterogeneity = 0.001) than in the whole population (I2 = 76.1%, Pheterogeneity = 0.001). Here, CYP11B2 is linked to atrial fibrillation.