Human type I IFN genes are located on chromosome 9p and, with an exception of IFN kappa, form a cluster upstream of the CDKN2A and CDKN2B tumor-suppressor genes and the noncoding antisense RNA encoded by CDKN2BAS. The region is frequently mutated and deleted in a wide variety of tumors and associated with melanoma [22], [23]. This evidence concerns the gene CDKN2B and melanoma.