Disulfiram increases self-reported ratings of psychostimulant aversion, such as anxiety, nervousness, paranoia, craving, and dysphoria in humans [1], [7], [19]–[24], and addicts with polymorphisms in the DBH gene that confer low DBH activity report higher levels of cocaine-induced paranoia [25], [26]. The gene discussed is DBH; the disease is dysphoria.