It is noteworthy that although YC-1 inhibition of HIF-1 seems to rescue the ischemia-induced retinal damage, and despite the plethora of published literature available showing the beneficial outcomes of inhibiting HIF-1 [56], [57]; several studies have indicated that inhibition of HIF-1 is detrimental during ischemic or hypoxic injury [58]. The gene discussed is HIF1A; the disease is ischemia.