MTOR and renal cell carcinoma: The most significant SNP associated with RCC risk was rs2295080, which is located in the promoter region of MTOR. Compared with individuals carrying the rs2295080TT genotype, individuals carrying the TG and TG/GG genotypes were both associated with a reduced risk of RCC (P = 0.021, OR = 0.81, 95%CI = 0.68–0.97 and P = 0.005, OR = 0.74, 95%CI = 0.59–0.91, respectively).