Additionally, the results of our study raise some important questions about, for instance, whether the distinct expression level of MTOR induced by the rs2295080 polymorphism will influence the phosphorylation level of mTOR and then alter its downstream signal, and whether this polymorphism has an effect on the RCC prognosis and the response of RCC patients to the treatment with temsirolimus and everolimus. Here, MTOR is linked to renal cell carcinoma.