Since PTEN negatively regulates the mTOR signaling pathway, we then investigated whether there was interaction between the MTOR rs2295080 and PTEN rs701848 in influencing RCC risk, however, as shown in Table 4, no significant interaction was observed (Pinteraction = 0.118), although individuals with both risk genotypes (rs2295080 TT and rs701848 CC) had a significantly increased RCC risk of 1.72. The gene discussed is PTEN; the disease is renal cell carcinoma.