17 Herbst Herbst A A ,  Wallner Wallner M M ,  Rahmig Rahmig K K ,  Stieber Stieber P P ,  Crispin Crispin A A ,  et al et al  ( 2009 2009 )  Methylation of helicase-like transcription factor in serum of patients with colorectal cancer is an independent predictor of disease recurrence Methylation of helicase-like transcription factor in serum of patients with colorectal cancer is an independent predictor of disease recurrence . This evidence concerns the gene HLTF and colorectal cancer.