Therefore, in the present study, we evaluated the diagnostic value of clusterin using plasma samples obtained at Skåne University Hospital, Sweden, from 171 controls, 127 patients with AD, 30 patients with depression, and 82 patients with other types of dementia (34 with Lewy Body dementia (DLB), 12 with Parkinson's disease with dementia (PDD), 17 with frontotemporal dementia (FTD), and 19 with vascular dementia (VaD)). Here, CLU is linked to major depressive disorder.