In the visual system, such evidence of dysfunction of the posterior visual pathways, i.e. LGN, OR and calcarine cortex, has been reported as secondary to loss of retina and/or optic nerve after enucleation of one eye [27], chronic glaucoma [28], [29], retinal degeneration [30], and optic neuritis [31]. The gene discussed is GPSM2; the disease is optic neuritis.