APOE and age-related macular degeneration: The somewhat inconsistent findings on the association of AMD and ApoE called for a recently published pooled analysis (n = 21.160) demonstrating that the E2 allele in homozygous form confers risk (OR = 1.83, 95%CI: 1.04–3.23) and the E4 allele is protective (OR = 0.72 per haplotype; 95%CI: 0.65–0.74) in late AMD [33].