HTRA1 and age-related macular degeneration: Strong association has been confirmed between AMD and the p.Ala69Ser (rs10490924) polymorphism in LOC387715 coding a protein of unknown function [19], [20] or a promoter SNP of the HTRA serine peptidase 1 (HTRA1) gene (rs11200638) [21], [22], [23], [24].