ENPEP and Alzheimer disease: In a triple transgenic mouse model of AD (3×TgAD, (APPSwe, PS1M146V, tauP301L)), APα was shown in vivo to reverse neurogenic deficits in both of the recognized postnatal proliferative zones of the brain – the subventricular (SVZ) and subgranular zone (SGZ), to levels comparable to the normal non-transgenic age-matched control [2], [3].