Apart from a currently lacking critical threshold, the quantification of the Treg cell ratio as an early sepsis marker cannot be expected to be superior to the widely used biomarkers like IL-6, procalcitonin or C-reactive protein, because the elevated Treg cell ratio is not specific for sepsis but has been shown to be elevated for instance in certain cancer patients such as hepatocellular carcinoma [35] and breast cancer [36]. This evidence concerns the gene CRP and hepatocellular carcinoma.