TNF and metabolic syndrome: Although the mechanism of the relationship between leukocyte and metabolic syndrome remained unclear, several explanations have been offered: a) Insulin resistance played an important role in metabolic disturbances [36], [37], leading to higher gathering of inflammatory markers, including the total leukocyte and other inflammatory factors, such as CRP, IL-6, tumor necrosis factor-α (TNF-α), As a result, statistical association between the total leukocyte and MetS in population can be detected [38], [39].