Thirdly, it is difficult to imagine the complexity of the tremendous pathway that from single gene polymorphism to human social behavior, they only selected the COMT gene rs4680 SNP, but the DA-related COMT gene contains a lot of functional SNPs, many of them (rs2239393, rs59938883, rs737865, rs4633, rs2020917) on the COMT gene are believed to be the risky genetic elements of schizophrenia [20]–[23], and rs174699 is correlated with drug-use behavior [24]. The gene discussed is COMT; the disease is schizophrenia.