Results of a study performed on 300 blood donors suggest that certain personality traits change with age differently in RhD-negative and RhD-positive subjects [23]. Another study has observed that the clinical picture of schizophrenia varies between RhD-negative and RhD-positive patients, namely that the RhD-negative female patients express more severe positive and reality distortion symptoms of the disease (measured with PANSS) and have a longer mean hospital stay than RhD-positive female patients [25]. The gene discussed is RHD; the disease is rheumatic heart disease.