Among these, a few gene-targeted pigs have been reported, such as cystic fibrosis pigs [28] and heterozygous fumarylacetoacetate hydrolase deficient pigs [29]as a disease model, and α1, 3-galactosyltransferase gene-knockout (KO) pigs [30] for organ transplantation [30], [31]. The gene discussed is FAH; the disease is cystic fibrosis.