In the final model, major depressive disorder was associated with AIDS-related stigma [(OR = 1.65, CI 1.20–2.26)], CD4+ counts of ≥200 [OR 0.43, (CI 0.20–0.91)] and a younger age [OR0.95, CI 0.92–0.98)]. The gene discussed is CD4; the disease is major depressive disorder.