MAPK3 and heart failure: Figure 6 represents an image of the merged networks overlaid for cardiac disorders. The key molecules IKBKB (NFKBIKB, IKKB) [48],[49] and [50] and MAPK3 [51] and [52] were reported to play an important role in cardiac disorders, such as heart failure, heart dilation, hypertrophy and apoptosis. SDRG were also subjected to canonical pathways analysis via IPA software (Fig. 7).