HLA-B and Epstein-Barr virus infection: [26], [27] It seems that this variant influences HLA peptide repertoire recognition and/or presentation for both HIV and EBV infections. The amino acid substitution in the heavy chain at position 116 could abolish the ability of P9 picket of HLA-B*35:01 to bind tyrosine but preferentially accommodate smaller hydrophobic residues such as methionine, valine, or leucine at the carboxy-terminal anchor had been shown by peptide-binding assays. [28]