APOA1 and amyloidosis: Using this approach in the CCHS, both F71Y, a known amyloidosis mutation [24], and A164S, a suspected amyloidosis mutation associated with increased risk of ischemic heart disease and early mortality [13], would have been assumed to be nonfunctional; 2) That variants in APOA1 associated with amyloidosis are relatively common in the general population.