Although keratinocytes produced IL-1β during the infection as detected by immunohistochemistry (Fig. S15), this amount of IL-1β was not able to promote effective neutrophil recruitment in the absence of IL-1β-expressing hematopoietic cells because wt mice reconstituted with bone marrow from IL-1β-deficient mice show the same impaired neutrophil recruitment response as normal non-irradiated/non-reconstituted IL-1β-deficient mice [11]. The gene discussed is IL1B; the disease is infection.