H2BC21 and type 1 diabetes mellitus: To evaluate the ability of the LCMV variants to cause T1D, we inoculated each of nine RIP-LCMV GP tg mice with 1×105 of LCMV GPV i.p., i.e., the variant in which both H-2b immunodominant GP33 and GP276 epitopes are knocked-out but the two subdominant GP CTL epitopes GP92 and GP118 remain.