CRP and age-related macular degeneration: Moreover, a more recent study has confirmed that native CRP-CFH interaction is evident at high plasma CRP concentrations (as happens during the acute-phase response, i.e., when the H402 protein inadequately binds to CRP) [118], and also a large meta-analysis has documented that serum levels of CRP >3 mg/L are related to a double AMD risk in comparison with CRP concentrations <1 mg/L [119].