N-MYC expression has been shown to be upregulated in four independent studies using PAX3-FOXO1 targeting siRNA in the ARMS cell line, RH4 [72], PAX3-FOXO1 overexpression in the RD (ERMS) cell line [73,81] and in ARMS versus non ARMS tumor cell lines [78]. The gene discussed is FOXO1; the disease is alveolar rhabdomyosarcoma.