This 12q13-15 region includes genes such as C/EBP-homolog and transcription factor CHOP/DDIT3/GADD153, sarcoma-amplified sequence and transmembrane 4 superfamily member SAS/TSPAN31, alpha 2-macroglobulin receptor A2MR/LRP1, Sonic hedgehog (SHH) pathway effector and zinc finger transcription factor GLI1, cyclin-dependent kinase cell cycle regulator CDK4 and p53 pathway modulator MDM2. The gene discussed is TSPAN31; the disease is sarcoma.