However, knockdown of FGFR4 in RMS cell lines does show a reduction in cell proliferation and an increase in apoptosis, suggesting that at later stages of ARMS tumorigenesis FGFR4 overexpression may interact with other unknown genetic lesions within these cell lines to induce pro-survival and proliferation effects [107]. This evidence concerns the gene FGFR4 and alveolar rhabdomyosarcoma.