DRD1 and diabetes mellitus: Their identified pharmacological activities were antagonistic against dopamine D1 receptor (gleditsioside F) [33], protective against acute myocardial ischemia (echinocystic acid) [32] or type 2 diabetes mellitus (aromadendrin) [35], antiallergic in mast cells (saponins) [41], and cytotoxic to leukemic cells (gleditsioside E) [38].