To identify the disulfide reductases/isomerases involved in HIV-1 infection of MDM and serving as potential targets for DTNB, the effects of specific monoclonal antibodies (mAbs) against PDI and/or Trx, two enzymes previously implicated in HIV-1 Env disulfude bond rearrangements[16-20] were evaluated. This evidence concerns the gene ERVW-1 and HIV-1 infection.