SF3B1 and B-cell chronic lymphocytic leukemia: Whole genome/exome sequencing technologies allowed for the identification of SF3B1 as a recurrently mutated gene in CLL.12,13,16SF3B1 mutations in CLL cluster in selected HEAT repeats of the SF3B1 protein, target a number of hotspots (codons 662, 666, 700, 742), and are generally represented by missense substitutions (Figure 1).12,13,16 Notably, an identical spectrum of SF3B1 mutations has been identified in other hematopoietic tumors of the myeloid compartment.62