We have measured significant amounts of n-9, n-6, and n-3 unsaturated fatty acids in lipid raft from both WT and APP/PS1 animals (Fabelo et al., 2012b), and also in human cortex from control and AD donors (Martín et al., 2010; Fabelo et al., 2011). Here, PSEN1 is linked to Alzheimer disease.