Furthermore, limited studies also suggest mice lacking mGluR5 show schizophrenia-related behaviors including abnormal locomotor patterns, reduced pre-pulse inhibition (PPI), and deficits on performance of a short-term spatial memory task on the Y-maze (Gray et al., 2009; Wang et al., 2009; Chen et al., 2010), suggesting that positive modulation of mGluR5 function would be a viable target for schizophrenia therapeutics. Here, GRM5 is linked to schizophrenia.