Studies have revealed that two de novo mutations in Shank3 are present in a subset of schizophrenia patients (Gauthier et al., 2010) and a Shank1 promoter variant leads to significant working memory deficits in schizophrenia (Durand et al., 2012; Lennertz et al., 2012), suggesting common Shank variants may contribute to neuropsychological dysfunctions in schizophrenia. Here, SHANK3 is linked to schizophrenia.