Multiple sclerosis seems to be associated with a predominantly Th1 cytokine pattern, characterized by increased levels of IFN-γ, TNF-α, IL-12, IL-23 and IL-27 as well as IL-6 and decreased levels of IL-10 and TGF-β [54-56], although other cell subsets such as Th17 cells, regulatory T cells and B cells also appear to be involved [57]. This evidence concerns the gene IFNG and multiple sclerosis.