TNF and cancer: Mirtazapine, in addition to representing a promising option for the treatment of cancer-related cachexia and anorexia [451, 452], has been proposed as a potential anticancer agent, both as an adjunctive treatment and as a molecule with direct effects itself, in glioblastoma [453], in osteosarcoma [454] and, more generally, during cancer immunotherapy; the drug-induced TNF increase could have a beneficial effect through the enhancement of antigen driven lymphocyte expansion [348].