IFNG and Behcet disease: Other diseases characterized by a Th1 polarized response are Behcet’s disease, in which there are increased levels of IFN-γ, IL-12 and IL-13 and reduced levels of IL-4 [78] as well as vitamin D [79], and IgA nephropathy, in which there is an increase in the ratio IFN/IL-10 and increased levels of IFN-γ, TNF, IL-1, IL-2 and IL-8 [80, 81].