TNF and Crohn disease: Furthermore, alterations of Th1/Th2 balance also appear to be relevant in the difference in clinical and pathophysiological presentation of diseases such as inflammatory bowel disease: the prevalence of a Th1 response involving overproduction of IL-12, IFN-γ and TNF-α manifests in the form of Crohn’s disease, while the prevalence of a Th2 response probably driven by overproduction of IL-13 manifests in the ulcerative colitis [156].