Levels of IL-6 in the serum of acute stroke patients have been reported to also correlate with stroke severity; serum concentrations of IL-6, IL-8 and IL-10 were higher in asphyxiated neonates; while cerebral ischemia initiates a Th1-prevalent inflammatory response associated with induction of a variety of cytokines, including TNF-α, IL-1β, IL-8, IL-18 and IL-6 [148-151]. Here, CXCL8 is linked to brain ischemia.