On the other hand, allergic diseases, such as asthma, allergic rhinitis, eczema and IgE-mediated food allergy, are characterized by dominant Th2 responses, with overproduction of IL-4, IL-5, IL-9 and IL-13, resulting in activation of mast cells (and consequent histamine release), eosinophils and shifting to IgE production [52, 53]. Here, IGHE is linked to allergic disease.