While an increase of IFN-γ was found in course of moderate hypercholesterolemia, severe hypercholesterolemia seems to be characterized by a Th2 shift, with an increase of IL-4 [111]: notably, cortisol and catecholamines, released during stress response, are involved in fat mobilization [112, 113]. The gene discussed is IL4; the disease is familial hypercholesterolemia.