FUS and amyotrophic lateral sclerosis: An exciting step forward in ALS genetics is represented by the recent discovery of mutations in TDP-43 (encoded by TARDBP) [16] and the related RNA-binding protein fused in sarcoma/translocated in liposarcoma (FUS) [17] in familial and sporadic cases that has shifted the focus of much research on RNA metabolism, and implicated abnormal RNA processing in ALS pathogenesis.