A study analyzing the association of the OGG1 S326C polymorphism in sporadic ALS found that both the C326 allele (p = 0.02) and the combined S326C + C326C genotype (OR = 1.65, 95% CI = 1.06–2.88) increased the risk of ALS [50]. This evidence concerns the gene OGG1 and amyotrophic lateral sclerosis.