It is likely, therefore, that the C-terminal ChM-I-like domain of TeM has anti-tumor activity in vivo, and indeed expression of both Ad-shTeM (the 116 amino acids of the human TeM C-terminal) and Ad-shChM-I (the 120 amino acids of the human ChM-I precursor C-terminal) result in the effective inhibition of angiogenesis, followed by suppression of tumor growth [20,23]. This evidence concerns the gene CNMD and neoplasm.