HIF-1 binds to its cognate enhancer sequence, the hypoxia-response element (HRE), and induces the expression of various genes related to the adaptation of cellular metabolism to hypoxia (the switch from oxidative to anoxic respiration: metabolic reprogramming) [6], escape from hypoxia (invasion and metastasis of cancer cells) [7,8], and improvement of hypoxia (angiogenesis) [9,10]. This evidence concerns the gene HIF1A and cancer.