Even more paradigmatic are the proteomic studies which defined in detail the epidermal growth factor receptor (EGFR) network, which is altered in various human cancers [14], and the breakpoint cluster region (BCR)-ABL1 network, responsible with few exception for the development of chronic myelogenous leukemia (CML) [26]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.