Interestingly, TNFR-2 pathway is an attractive drug target for autoimmune diseases, since its expression is restricted only to certain immune-cell populations, which could mean less side-effects than with the use of TNF-alpha alone, that acts on both, ubiquitously expressed TNFR-1 and more limited TNFR-2 [18]. This evidence concerns the gene TNFRSF1B and autoimmune disease.