Indeed, several attempts have been made to use neurotrophin-related pathways in therapy for other CNS disorders with a degenerative component, in which decreased neurotrophic activity was described, namely AD, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease [63–67]. The gene discussed is BDNF; the disease is amyotrophic lateral sclerosis.