Similarly, Lee et al. [233] reported that TI inhibited migration, invasion and MMPs activity in macrophage conditional medium-stimulated CL1-5 lung cancer cells in vitro, and reduced the tumorigenesis and metastasis of CL1-5 lung cancer xenografts in severe combined immunodeficient (SCID) mice, in association with reduction of interleukin-8 (IL-8, an angiogenesis factor promoting angiogenesis and metastasis). This evidence concerns the gene CXCL8 and lung cancer.