Similar observations were made by others, in that CT and PTS33 (a sodium salt derivative of CT with increased water-solubility for structure) at low concentrations (<2 μM) inhibited AR-dependent transcription without affecting AR protein level; however, at higher concentrations (5–10 μM) promoted AR degradation in LNCaP prostate cancer cells [262–264]. The gene discussed is AR; the disease is Familial prostate cancer.