ERBB2 and malignant colon neoplasm: TIIA was reported to decrease ErbB-2/HER2/Neu in Colo205 colon cancer xenograft tumors in male severe combined immunodeficient (SCID) mice (20 mg/kg of TIIA in corn oil, oral gavage, once per day for 30 days) [141], but not in MCF-7 and MDA-MD-231 breast cancer xenograft tumors in female nude mice (30 mg/kg of TIIA in Tween 20:ethanol = 1:99, subcutaneous (s.c.)injection, four times per week for four weeks) [137].