Moreover, combination of TIIA with a PI3K inhibitor (LY294002) enhanced TIIA-induced apoptosis in LNCaP and PC-3 prostate cancer cells which contained high AKT, but did not in MDA-MB-231 breast cancer cells which contained undetectable AKT, suggesting a possible involvement of PI3K/AKT survival pathway [133]. This evidence concerns the gene AKT1 and breast carcinoma.