Thus, Caceres et al. [9] using the panel of 6 TSGs: BRCA1, RASSF1A, APC, p14ARF, p16INK4A and DAP-Kinase, demonstrated that promoter hypermethylation is common in ovarian cancer, including stage I disease, and can be readily detected in a specific manner in serum and peritoneal fluid DNA. Here, APC is linked to ovarian cancer.