We selected novel epigenetic markers including NKIRAS1/RPL15, THRB RBPS3 (CTDSPL), IQSEC1, NBEAL2, ZIC4, LOC285205, CGGBP1, EPHB1 and FOXP1 that allowed detection of cancer in ovarian biopsies on all stages with sensitivity equal to (72 ± 11)% and specificity (94 ± 5)%. This evidence concerns the gene ZIC4 and cancer.