In a recent study, Murname et al. [107] demonstrated that also active MMP-2 activity might allow discrimination of colonic mucosa, adenomas with and without HGD and CRC, concluding that the ability of active MMP-2 to distinguish adenomas with HGD from adenomas without HGD may be essential in predicting additional CRC risk for an individual patient. This evidence concerns the gene MMP2 and adenoma.