Another study by the same group using human brain samples (11 type 2 diabetes mellitus (T2DM), 10 AD, 8 T2DM and AD and 7 controls) showed that the T2DM brain had a decreased level of neuronal GLUT3 protein in comparison to the AD brain and that the decrease in O-GlcNAcylation which was observed in the AD brain was also visible in the T2DM brain [130]. The gene discussed is SLC2A3; the disease is Alzheimer disease.