Indeed, it was shown that a blockade of ANGII signaling attenuates the development of pulmonary and renal fibrosis [76,77,87], and, in contrast, administration of ANGII into the mouse potentiates perivascular and interstitial renal fibrosis, most likely via aggravation of PRMT1, which did not, however, alter ADMA levels in blood circulation [88]. The gene discussed is AGT; the disease is renal fibrosis.