Multiple cytokines and growth factors, such as transforming growth factor (TGF)-β1, interleukin (IL) -4, -13, -21 [75] and angiotensin II (ANGII) [76,77] have been identified as potent regulators of fibrotic processes, directly or indirectly, for example, by regulation of the expression of coagulation factors which in turn contributes to the development of IPF [78–80]. Here, AGT is linked to idiopathic pulmonary fibrosis.