STE(104-113), G123P, KH→II(K110H111 to I110I111 substitutions), AV3(V113V115V118 to A113A115A118 substitutions), A117V (human GSS) and N108I (human CJD) on hamster PrPC [45,46]. The gene discussed is PRNP; the disease is Creutzfeldt Jacob disease.