Viral proteins that encode P[T/S]AP late domains gain access to the ESCRT pathway through interaction with the ESCRT-I component Tsg101 (tumor susceptibility gene 101) [138,139,140], while the YxxL motif mediates binding to Alix/AIP1, which is an ESCRT-I and III binding partner [141,142,143]. The gene discussed is PDCD6IP; the disease is neoplasm.