In regards with IFN induction, no difference could be detected between PKRwt and PKR deficient mice, either after injection of the synthetic dsRNA, polyinosinic acid: Polycytidylic acid (polyrI-polyrC) or infection with Newcastle Disease Virus (NDV) as shown by induction of type I IFN in several tissues (lung, liver, spleen). Here, IFNA1 is linked to infection.