PPIG and infection: Clinical studies conducted to date, and especially those conducted with Alisporivir, have established that the addition of a potent Cyp inhibitor to a background regimen comprised of pegylated interferon and ribavirin improves SVR in multiple patient groups including treatment-naïve patients with genotype 1 infection, nonresponders/relapsers with genotype 1 infection, and treatment-naïve patients with genotype 2 or 3 infection.