Further study by Deng et al. demonstrated that infection of the HCV J6/JFH1 chimeric strain into Huh7.5-1 cells induces apoptosis which is associated with activation of caspase 3 and the cleavage of poly(ADP-ribose) polymerase (PARP), a downstream substrate of the activated caspase 3 [115] (Table 3). Here, CASP3 is linked to infection.