HCV mainly targets hepatocytes and its infection is mediated by several entry cofactors located on the cell surface, including the tetraspanin CD81, the scavenger receptor class B member I (SR-BI), Claudin 1 (CLDN1), and Occludin (OCLN) [3,4,5,6] (Figure 1B). Here, CLDN1 is linked to infection.