STX2 and bacterial infectious disease with sepsis: Enterohemorrhagic E. coli (EHEC) are not invasive, so bacteremia is rare, but they secrete ribosome inactivating Shiga-like toxins (Stx1 and Stx2 with variants) which are responsible for much of the organ damage [4,5], and Stx2 is more frequently associated with severe disease.