STX1A and hemolytic-uremic syndrome: In the baboon model of Stx challenge which presents with all manifestations of HUS [48], glomerular injury after Stx1 and Stx2 challenge featured prominent HUS-like capillary wall changes, including thickening of the glomerular basement membrane and double contouring with prominent thrombus formation, and severe endothelial injury with diffuse cell swelling and focal endothelial denudation (Figure 3).