This O104:H4 strain was a combination of an enteroaggregative E. coli strain, normally characterized by intestinal mucosa adherence to cause self-limiting diarrhea [13], that picked up the stx2 gene, thereby acquiring high virulence and causing severe clinical consequences, particularly acute kidney injury from hemolytic uremic syndrome and severe neurological abnormalities [14,15]. Here, STX2 is linked to hemolytic-uremic syndrome.