For example, TRAF6, a molecule containing E3 ligase properties, is regulated through S-glutathionylation [96], suggesting that alterations in glutathionylation status under oxidative stress would impair clearance of TRAF6-dependent substrates, and indeed TRAF6 has been implicated in Lewy body formation in PD [97]. Here, TRAF6 is linked to Parkinson disease.