After exclusion of inevaluable cases due to tissue loss or inadequate tissue, the positive rates of ERα, ERβ, PR and AR expression in normal tissues were 38.3%, 97.3%, 30.5%, and 52.7%, and the positive rates of the four receptors in gastric tumor were 12.0%, 91.9%, 23.3%, and 33.0%, respectively. The gene discussed is ESR1; the disease is gastric neoplasm.