Sleep—a component of vitality—is often disturbed in patients with diabetes, particularly in individuals experiencing high rates of nocturnal hypoglycaemia, and, given that insulin degludec has shown a reduced rate of nocturnal hypoglycaemia compared with insulin glargine, the present study may underestimate this component of health-related quality of life with insulin degludec, as it did not specifically isolate the overnight period in the evaluation 14,20. Here, INS is linked to diabetes mellitus.