A broad spectrum of metabolic and biochemical changes in PCOS subgroups compared with the control group were indicated, including the obviously enhanced triglyceride and low-density lipoprotein (LDL) level and reduced HDL level, a marked augment in serum concentrations of androgens such as androstenedione, increased ratio of luteinizing hormone (LH) to follicle-stimulating hormone (FSH). The gene discussed is BRD2; the disease is polycystic ovary syndrome.